In October 2005 the USPTO's own administrative judges overturned this position in a majority decision of the board in Ex Parte Lundgren, Appeal No. 2003-2088 (BPAI 2005).
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This was based on an unpublished decision of the U.S. Board of Patent Appeals and Interferences, Ex Parte Bowman, 61 USPQ2d 1665, 1671 (Bd Pat. App. & Inter. 2001).
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Flashpoints have included the patenting of naturally occurring biological material, genetic sequences, stem cells, "traditional knowledge," programs for computers, and business methods.
State Street Bank v. Signature Financial Group, a US court decision relating to a business method patent