JNK3 is found mainly in the brain, but is also found in the heart and the testes.
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Downstream molecules that are activated by JNK include c-Jun, ATF2, ELK1, SMAD4, p53 and HSF1.
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TRAF6 activates NF-κB transcription factor ‘Mitogen Activated Protein Kinases’ (MAPK) and ‘c-jun NH2 Terminal Kinases' (Jnk) which activates the transcription factor ‘Activating Transcription Factor 2’ (ATF2).