To make this diagnosis under its present system of classification, the WHO the presence of "hallmark" cells and immunopositivity for CD30.
Immunohistochemical panels for the diagnosis of Hodgkins disease typically employ CD15 along with CD30 and CD45; the latter does not stain Reed-Sternberg cells, but does stain almost all other lymphoid cells.
The molecule is bound to a tumour cell via the tumour antigen CD30 and to a macrophage via an Fc receptor.
Iratumumab is a human monoclonal antibody used in the treatment of oncological diseases such as relapsed refractory CD30-positive lymphoma including Hodgkin's disease.
Unlike classic RSC, the non-classic popcorn-shaped RS cells of NLPHL are CD15 and CD30 negative while positive for the B cell marker CD20.
CD30 |