APC/C activator protein CDH1 Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C)
Suppression of Cdh1 by RNA interference leads to an aberrant accumulation of APCCdh1 target proteins, such as cyclin A and B, the kinase AuroraB, PLK1, Skp2 and Cdc20, another APC/c co- activator.
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Cdh1 also contains a C-terminal Ile-Arg (IR) dipeptide motif at residue 565 and 566, which is suggested to bind to the Cdc27 subunit of APC.