The existence of a central governor over physiology has been questioned since ‘physiological catastrophes’ can and do occur in athletes (important examples in marathons have been Dorando Pietri, Jim Peters and Gabriela Andersen-Schiess).
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Noakes is also known for renewing and elaborating the idea first proposed by the 1922 Nobel Prize in Physiology or Medicine winner Archibald Hill that a central governor regulates exercise to protect body homeostasis.