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The candidate is being developed with a Toll-like receptor 3 (TLR3) agonist adjuvant for multiple indications, including cervical intraepithelial neoplasia (also known as cervical dysplasia or CIN), genital warts, cervical cancer, and head and neck cancers.
Jian Zhou (1957–1999) (in Chinese convention Dr. Zhou Jian) was a Chinese virologist and cancer researcher, who with Australia’s Ian Frazer invented Gardasil and Cervarix, the vaccines for stimulating human immunological resistance to the cervical cancer-inducing human papilloma virus .
Nventa is developing HspE7 in combination with the Toll-like receptor 3 (TLR3) agonist adjuvant Poly-ICLC for multiple indications, including Cervical Intraepithelial Neoplasia (also known as cervical dysplasia or CIN), Genital Warts, Cervical Cancer, and head and neck cancers.
In May 2013 Harper received the Prix Monte-Carlo Woman of the Year award in Monte Carlo for her contributions and discoveries defining the role of HPV in the pathology of cervical cancer.
An infection with one or more high-risk HPV types is believed to be a prerequisite for the development of cervical cancer (the vast majority of HPV infections are not high risk); according to the American Cancer Society, women with no history of the virus do not develop this type of cancer.
O'Toole has sponsored laws to reform welfare, strengthen domestic violence statutes, increase penalties on businesses and individuals who engage in discrimination, mandate insurance coverage for mammography and for treatment of breast and cervical cancer, preserve the state's drinking water supply through the preservation of Sterling Forest, and create more government transparency.
An article by Johnston in the Sunday Express that was critical of the cervical cancer vaccine, Cervarix, was the subject of a complaint to the Press Complaints Commission in 2009.