Before merging with another company in 1991, it developed several significant pharmaceutical drugs as well as a revolutionary DNA amplification technique.
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Its inventor received the Nobel Prize in 1993, the only one awarded for research performed at a biotechnology company.
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By the late-1970s, however, three new revolutionary techniques had been developed: recombinant DNA, monoclonal antibodies, and gene expression, the foundations of the biotechnology industry.
Following Shell's 1972 departure from its Emeryville campus, its facilities languished briefly, then became an early home of biotechnology pioneers Cetus and Chiron.
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In December 1999, U.S. District Judge Vaughn Walker ruled that the 1990 patent involving Taq polymerase was issued, in part, on misleading information and false claims by scientists with Cetus Corporation.