After appearing in Halloween in 1978, Cyphers worked with Carpenter two years later, playing Dan O'Bannon in The Fog, a 1980 horror film which also starred Tom Atkins, Cyphers's fellow Halloween cast member Jamie Lee Curtis, his Assault on Precinct 13 co-star Darwin Joston, and Nancy Kyes, who worked with Cyphers in both Assault on Precinct 13 and Halloween.
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He then played the Secretary of State in Carpenter's popular 1981 film Escape from New York, in which he appeared with Atkins and Halloween actress Nancy Stephens.
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In 2005, he appeared in the movie Dead Calling, and in 2007 he appeared as a Sheriff in Ethan Dettenmaier's forthcoming film, Sin-Jin Smyth, and in the film Methodic in a role which paid homage to his character in Halloween.
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Cyphers' roles on the stage, both on- and off-Broadway, include 12 Angry Men...in which he portrayed "Juror #3" to Julie Cobb's "#2" (her father portrayed "#3" in the 1957 movie).
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