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He coincided with the final months of Gian Gastone de' Medici, the last Medici Grand Duke.
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He succeeded his father in 1744 to estates in near Tandragee in county Armagh; near Lough Gur in county Limerick; at Basildon House in Berkshire; and near Tiverton in Devon.
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He was in Florence in person between 3 October 1734 and spring 1738; when Horace Walpole's later friend Horace Mann, his deputy, replaced him (as the Chargé d'Affairs).