Among his best known paintings are The Decapitation of St John the Baptist (1881), in the Art Institute of Chicago; Prayer (1884), The Return of the Flock, and Meditation.
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He received medals at the Paris Salon and elsewhere, and was made Chevalier of the French Legion of Honor, decorated with the Order of Leopold, Belgium, the Order of the Red Eagle, Prussia, and the Order of the Dannebrog, Denmark.
Although 13 years his junior he remained close to his older brother, the noted American expatriate painter, Charles Sprague Pearce.
The Ruth B. Zigler Memorial Wing - also called the Fine Arts Gallery, houses a collection of American and European masterpieces by such painters as Anthony van Dyck, John Constable, George Inness, Rembrandt Van Rijn, Charles Sprague Pearce, Helen Turner, Albert Bierstadt, Camille Pissarro, Maurice de Vlaminck and Albrecht Dürer.
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