Since the timetable change on 10 December 2006, the Franken-Sachsen-Express Interregio-Express service operates on the line, using class 612 diesel multiple units (DMUs), from Nuremberg via Bayreuth or Marktredwitz to Hof, continuing via Chemnitz to Dresden, replacing an InterCity service.
Chemnitz | Berlin Hauptbahnhof | Zürich Hauptbahnhof | Mainz Hauptbahnhof | Hamburg Hauptbahnhof | Gütersloh Hauptbahnhof | Chemnitz Hauptbahnhof | Reutlingen Hauptbahnhof | Martin Chemnitz | Leipzig Hauptbahnhof | Chemnitz University of Technology | Bremen Hauptbahnhof | Würzburg Hauptbahnhof | Lünen Hauptbahnhof | Lübeck Hauptbahnhof | Koblenz Hauptbahnhof | Innsbruck Hauptbahnhof | Hartmannsdorf (Chemnitz) | Freiburg Hauptbahnhof | Chemnitz Opera |
Two locomotives have been preserved: number 75 501 by the German Steam Locomotive Museum at Neuenmarkt-Wirsberg, which was loaned to the Schwarzenberg railway museum in 2002 and number 75 515 by the Saxon Railway Museum in Chemnitz-Hilbersdorf, which was badly damaged in a shunting accident on 14 June 1983 at Karl-Marx-Stadt Hauptbahnhof.