In Rome, he was favored with the patronage of Cardinal Chigi.
The Library Hall was commissioned by Agostino Chigi at the end of the 17th century in order to house the enormous library of cardinal Flavio Chigi.
He was patronized by the Marchese Giovan Battista Salimbeni of Siena, as well as the cardinals Alessandro Chigi Zondadari and Neri Corsini.
He completed the stucco decoration of San Tomaso di Villanova in Castel Gandolfo (1660-1), the stucco decoration of Bernini's Sant'Andrea 1662-1665), the statues of Saint Bernardino and Pope Alexander VII Chigi for Duomo di Siena and the Virgin and Child in Saint Joseph des Carmes in Paris (1650–51).
The Italian painter and engraver Bernardino Mei (1612/15 – 1676) worked in a Baroque manner in his native Siena and in Rome, finding patronage above all in the Chigi family.
The Judgement of Paris on the Chigi vase is the earliest extant depiction of the myth, evidence perhaps of knowledge of the lost epic Kypria from the 650s.
Together with the well-known scriptural scholar Carlo Vercellone, he supervised the printing of the Greek text of the Codex Vaticanus, in five volumes (Rome, 1868–81); he also edited other scriptural manuscripts, e.g. the Greek codex of Daniel in the Chigi Library at Rome.
He frescoed for the chapel in the Palazzo Chigi in Formello .
The Quintet had the use of the four best instruments from Count Chigi-Saracini's private collection, namely a Camillo Camilli and a Guadagnini violin, an Amati viola and a Stradivarius violoncello.