In 1984 John T. Lis and David Gilmour, at the time a graduate student in the Lis lab, used UV irradiation to covalently cross-link proteins in contact with neighboring DNA in intact living bacterial cells.
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Matrix ChIP: This is a microplate-based ChIP assay with increased throughput and simplified the procedure.
Microarray-based readout of chromatin immunoprecipitation (ChIP-chip) for high-throughput binding-site determination relies on specific antibodies which may not always be available.
On the other hand, analysis of FOXP2, using the chromatin immunoprecipitation technique, revealed that it binds onto and directly down-regulates expression of CNTNAP2, a gene found to be associated with nonsense-word repetition, a major marker of SLI.