Kidney stones, which sometimes may lead to more severe condition including kidney failure;
Lori Hartwell is the Founder and President of the Renal Support Network, author of Chronically Happy: Joyful Living in Spite of Chronic Illness, and co-host of KidneyTalk, a biweekly webcast of issues of interest to those with Chronic Kidney Disease (CKD).
McCool originally developed STI for patients with end-stage renal disease (ESRD).
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Bardoxolone methyl was previously being investigated by Reata Pharmaceuticals, Inc. in partnership with Abbott Laboratories and Kyowa Hakko Kirin, as an experimental therapy for advanced chronic kidney disease (CKD) in type 2 diabetes mellitus patients.
In preliminary experiments, this investigational drug was reported to significantly increase estimated glomerular filtration rate (GFR), and improve several other markers of kidney function in patients with chronic kidney disease (CKD).
The APOL1 gene has been proposed as a major genetic risk locus for a spectrum of nondiabetic renal failure in individuals of African origin, these include HIV-associated nephropathy (HIVAN), primary nonmonogenic forms of focal segmental glomerulosclerosis, and hypertension affiliated chronic kidney disease not attributed to other etiologies.