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16 unusual facts about Huntington's disease


Carol Carr

Carol Scott Carr (born 1939) is an American woman from the state of Georgia who became the center of a widely publicized debate over euthanasia when she killed her adult sons because they were suffering from Huntington's disease.

Cell therapy

Neural stem cells (NSCs) are the subject of ongoing research for possible therapeutic applications, for example for treating a number of neurological disorders such as Parkinson's disease and Huntington's disease.

Charlotte Raven

In January 2010 she revealed that she had been diagnosed with Huntington's disease, an incurable hereditary disease, in January 2006 and had been contemplating suicide, an option she rejected after visiting a clinic in an area of Venezuela with a very high incidence of Huntington's Disease.

CHDI

CHDI Foundation, a US non-profit foundation that aims to develop treatments for Huntington's disease

Cortney Lance Bledsoe

His mother, Wilma Jean Maupin Bledsoe, suffered from Huntington's disease.

Dizocilpine

Thus NMDA receptor antagonists including MK-801 have been extensively studied for use in treatment of diseases with excitotoxic components, such as stroke, traumatic brain injury, and neurodegenerative diseases such as Huntington's, Alzheimer's, and amyotrophic lateral sclerosis.

Huntington's Disease Outreach Project for Education at Stanford

The Huntington’s disease Outreach Project for Education at Stanford (HOPES) is a student-run project at Stanford University dedicated to making scientific information about Huntington's disease (HD) more readily accessible to patients and the public.

Hyperkinesia

Hyperkinesia is a state of excessive restlessness which is featured in a large variety of disorders that affect the ability to control motor movement, such as Huntington's disease.

Hyperkinesia, more specifically chorea, is the hallmark symptom of Huntington's disease, formerly referred to as Huntington’s chorea.

Janine Fuller

Following a diagnosis with Huntington's disease in the late 2000s, Fuller has also become an activist and speaker on issues relating to the condition.

Mendelian error

Examples of such diseases in humans caused by single genes are Huntington's disease or Marfan syndrome.

Muscimol

In patients with Huntington's disease and chronic schizophrenia, oral doses of muscimol have been found to cause a rise of both prolactin and growth hormone.

Richard I. Morimoto

Consequently, these studies provide a molecular basis to elucidate the underlying mechanisms of neurodegenerative diseases including Huntington's disease, Parkinson's disease, ALS, and Alzheimer's disease.

Robley Dunglison

One of Dunglison's recently graduated students at Jefferson Medical College, Charles Oscar Waters, provided his professor with a description of the "magrums" (a folk name for what is now called Huntington's disease), which Waters knew from his travels in Westchester County, New York.

Rudolph E. Tanzi

Tanzi has been investigating the genetics of neurological disease since the 1980s when he participated in the first study that to use genetic markers to find a disease gene (Huntington's disease).

The Movement Disorder Society

The field of Movement Disorders includes the following areas: Parkinson's disease and parkinsonism, ataxia, dystonia, chorea and Huntington's disease, tics and Tourette syndrome, myoclonus and startle, restless leg syndrome, stiff person syndrome, tremor and essential tremor, and gait disorders.


Angus Reid

Reid missed three years of college football at Simon Fraser because of gastrointestinal problems linked to Crohn's disease but he played every CFL game from the 2002 to 2008 CFL seasons including the 92nd and 94th Grey Cups.

Antanas Mockus

On 9 April 2010 he announced that he had been diagnosed with Parkinson's disease.

APOE

Apolipoprotein E, a main apoprotein of the chylomicron, also studied for its involvement in Alzheimer's Disease risk.

Arthur O'Connell

At the time of his death from Alzheimer's disease in California in May 1981, O'Connell was appearing by his own choice solely in these commercials.

ASAH2B

ASAH2B shows reduced expression with increasing age and further reduction in late onset Alzheimer's disease patients.

Bugula

In January 2008 a clinical trial was submitted to the United States National Institutes of Health to measure the safety and effectiveness of Bryostatin 1 in the treatment of Alzheimer's Disease.

Center for BrainHealth

All contributions support the cause of brain health and the Center’s many research focus areas-Alzheimer's disease, traumatic brain injury (TBI), autism, Attention Deficit Hyperactivity Disorder (ADHD), stroke, Post-Traumatic Stress Disorder (PTSD), Addiction, BrainHealth Physical, Dementia, Exercise and the Brain, Healthy Brain Aging, and Virtual Brain Training.

Cerlapirdine

Cerlapirdine (USAN; SAM-531, WAY-262,531, PF-05212365) is a drug which is under development by Wyeth/Pfizer for the treatment of cognitive disorders associated with Alzheimer's disease and schizophrenia.

Charles Enrique Dent

He began research into a hereditary disease of the kidneys which was greatly expanded by his pupil Oliver Wrong and named Dent's disease.

Charles Stoneham

For several years before his death, Stoneham had been suffering from a variety of physical ailments which were eventually diagnosed as symptoms of Bright's disease.

Charles W. Morse

In 1912 Morse became ill, and a panel of Army doctors declared that he suffered from Bright's disease and other maladies and would soon die if he remained in prison.

Clifford Bias

Born in Huntington, West Virginia in 1910, he claimed that since the age of five he had been able to communicate with people who had long since died.

Colin Diver

He was named the college's 14th president on October 5, 2002, replacing acting president Peter Steinberger, dean of Faculty, and succeeding Steven Koblik, who departed Reed College to run the Huntington Library in San Marino, California.

Conghua city yueyuan animal breeding farm

The monkeys are used scientific research, including gene therapy, cancer, Parkinson's, Alzheimer's, stem cells and antibody-based treatments.

Daniel Bekker

Bekker died on 22 October 2009 after a long struggle with Parkinson's and Alzheimer's diseases.

First Cousin Once Removed

Documentary about the life of poet, translator, critic and university professor Edwin Honig and his struggles with Alzheimer's disease.

George Hartford

George Ludlum Hartford (1864–1957), son and successor of George Huntington Hartford

HDBuzz

Emmy award-winning journalist and Huntington's disease advocate Charles Sabine is a Consulting Publisher to HDBuzz.

Hereditary Disease Foundation

In 1968, after experiencing Huntington's disease (HD) in his wife's family, Dr. Milton Wexler was inspired to start the Hereditary Disease Foundation, with the aim of curing genetic illnesses by coordinating and supporting research.

Hoxton Square

James Parkinson (1755–1824), the physician and author of An Essay on the Shaking Palsy, the subject of which is now known as Parkinson's disease, was in practice at 1 Hoxton Square, which is commemorated with a blue plaque on the site.

Huntington Castle, Clonegal

Larger plantings have resulted in Huntington possessing a number of great Irish trees, including varieties of hickory, a cut leaved oak, Siberian crab and buckeye chestnut.

Huntington family

Huntington Avenue, after Ralph Huntington (1784–1866), in Boston, Massachusetts

Huntington Park

Mount Rubidoux, a city park in Riverside, California, formerly known as Huntington Park

Ironton–Russell Bridge

Soon, the Ironton-Russell bridge was followed by numerous others at Ashland, Portsmouth, and Huntington.

Jean Kasem

In October 2013, Kerri Kasem, one of Casey Kasem's three children from his first marriage, said her father was suffering from Parkinson's disease.

Joseph Jankovic

In 1977 he joined the faculty of Baylor College of Medicine and became a founder and director of the Parkinson's Disease Center and Movement Disorders Clinic, which has since been recognized as a "Center of Excellence" by the National Parkinson Foundation and the Huntington Disease Society of America.

Kim Wolfe

Mayor Kim Wolfe was defeated by then-City Councilman, and former WV Delegate and Huntington City Manager, Steve Williams on November 6, 2013.

Larry Whiteside

Whiteside developed Parkinson's disease early in the 21st century, which led to the end of his career with The Boston Globe in 2004.

Low-threshold spikes

Therefore, much research has been conducted on low-threshold spikes in the neurons in the thalamus and how it could relate to Parkinson's disease and the corresponding loss of motor function.

Mieczysław Weinberg

Towards the end of his life, Weinberg suffered from Crohn's disease and remained housebound for the last three years, although he continued to compose.

Music therapy for Alzheimer's disease

Music therapy (MT) is one of the most common treatments for Alzheimer's disease (AD).

Mycobacterium avium subspecies paratuberculosis

On the assumption that MAP is a causative agent in Crohn's disease, the Australian biotechnology company Giaconda is seeking to commercialize a combination of rifabutin, clarithromycin, and clofazimine as a potential drug therapy, called Myoconda, for Crohn's.

Nuckle Brothers

The Nuckle Brothers were a third wave ska band from Huntington Beach that was part of the early 1990s Orange County, California music scene, inspiring such bands as Reel Big Fish, Save Ferris and The Aquabats.

Parkinson Association of the Rockies

The Parkinson Association of the Rockies (PAR) is a Colorado care and research not-for-profit organization whose aim is to enhance the quality of life for individuals with Parkinson's disease through education, research, awareness and support for those with Parkinson's disease, their families and the community.

Philippe Gaucher

Gaucher is remembered for his description of the disorder that was to become known as Gaucher's disease.

Protein losing enteropathy

Causes of protein losing enteropathy include celiac disease, Crohn's disease, short bowel syndrome (where the absorptive area for proteins is decreased), intestinal lymphangiectasia, amyloidosis, enteropathy caused by NSAIDs, Ménétrier's disease, dyskeratosis congenita, IPEX and giardiasis.

Rivastigmine

Rivastigmine (sold under the trade name Exelon) is a parasympathomimetic or cholinergic agent for the treatment of mild to moderate dementia of the Alzheimer’s type and dementia due to Parkinson's disease.

Robert H. Plymale

He appeared on Jamie Oliver's Food Revolution — Episode 3 as the State Senator who dined at a meal prepared by high school students from Huntington, WV.

Rogelio Frigerio

Frigerio lost his friend, Arturo Frondizi, to Parkinson's disease in 1995, and his own health declined subsequently.

Rowland George

Sylvia Beatrice Norton, daughter of Cecil Norton, 1st Baron Rathcreedan and Marguerite Cecil Huntington, at St Mary's Henley on 22 April 1933 and had three sons and a daughter.

Solid-state nuclear magnetic resonance

Membrane proteins and amyloid fibrils, the latter related to Alzheimer's disease and Parkinson's disease, are two examples of application where solid-state NMR spectroscopy complements solution-state NMR spectroscopy and beam diffraction methods (e.g. X-ray crystallography, electron microscopy).

Synaptic fatigue

Hallmarks of Alzheimer's disease (AD) are impairment of cognition, aggregation of β-amyloid peptide (Aβ), neurofibrillary degeneration, loss of neurons with accelerated atrophy of specific brain areas, and decrease of synapse number in surviving neurons.

Tara Devi

After this tragedy, she became physically unfit and later was diagnosed with Parkinson's disease.

The Art of Cross-Examination

The cross-examination of Ada and Phoebe Brush by George W. Whiteside - in their suit against two prominent Huntington, Long Island physicians, to recover damages for their ten-year incarceration in Kings Park State Hospital as insane patients.

Thioflavin

The dye is widely used to visualize and quantify the presence of misfolded protein aggregates called amyloid, both in vitro and in vivo (e.g., plaques composed of amyloid beta found in the brains of Alzheimer's disease patients).

WSAZ-TV

Radio engineer Glenn Chase applied to the Secretary of Commerce for a license to operate a small radio station in Pomeroy, Ohio (it moved down and across the Ohio River to Huntington in 1927).