When the season ended, he was continuously linked with various clubs, but Director of Sport Alessio Secco ended all speculation by listing him as one of the "untouchable" players.
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In November, he scored his first ever goal in a European competition in the Group Stage home fixture against FC Nordsjælland.
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After a good 2011–12 season, Marchisio was named in the final squad for UEFA Euro 2012 and started every match in Italy's surprise run to the tournament finals, where they were defeated 4–0 by reigning European and world champions Spain.
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He scored a 12-yard volley at the 2008 Toulon Tournament against Turkey in a 2–1 win and was called up to the Olympics that summer but was forced to return home due to an injury.
Claudio Monteverdi | Claudio Roditi | Claudio Arrau | Claudio Reyna | Cláudio Taffarel | Claudio Scimone | Claudio Procesi | Claudio Baglioni | Claudio Lolli | Claudio Cecchetto | Claudio Magris | Claudio Naranjo | Sergio Claudio dos Santos | Claudio Marrero | Claudio Marchisio | Claudio Chiappucci | Claudio Bravo | Claudio Bisio | Claudio Vargas | Claudio Treves | Claudio Taffarel | Claudio Stampi | Claudio Scarchilli | Claudio Scajola | Claudio Saracini | Claudio Sanchez | Claudio R. M. Costa | Claudio Ranieri | Claudio Prieto | Claudio Osorio |
He came under intense scrutiny from the media and there was much speculation about who would succeed him as manager, especially after he was absent at the traditional meeting of all Serie A managers, coaches and referees in Rome during mid-season and was instead represented by then Director of Sport Alessio Secco and 23-year-old homegrown midfielder Claudio Marchisio at the press conference.
The goal consisted of him starting the run from his own area, outpacing defenders Claudio Marchisio and Andrea Barzagli and beating goalkeeper Marco Storari.