They negatively regulate the expression of several genes encoding outer membrane proteins, including cirA, CsgD, fecA, fepA and ompT by binding in the vicinity of the Shine-Dalgarno sequence, suggesting the control of these targets is dependent on Hfq protein and RNase E.
The transcriptional regulator CsgD is central to Biofilm formation, controlling the expression of the curli structural and export proteins, and the Diguanylate cyclase, adrA, which indirectly activates cellulose production.