Wilson and DenBleyker have mentioned the traditional comic The Far Side by Gary Larson and the webcomic The Perry Bible Fellowship by Nicholas Gurewitch, as some of their influences for the comic.
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It has appeared on social networking sites that include Myspace, LiveJournal, and Facebook where, in April 2006, it had generated more than a million visits per week.
Rob DenBlyker, one of the creators of the webcomic Cyanide and Happiness, parodied the commercial in a 2013 installment where a father, after re-enacting the commercial, admits to his son that he himself is on drugs.
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