Cytotoxicity can also be monitored using the 3-(4, 5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) or MTS assay.
Since methylglyoxal is highly cytotoxic, the body developed several detoxification mechanisms.
Fraction S2 contains two phospholipases A2 — PLA2 I and PLA2 II; fraction S3 contains four cytotoxin homologues — maticotoxins A, C, D1 and D2; and fractions S4 and S5 contain a large amount (about 1 mg/specimen) of adenosine with smaller amounts of inosine and guanosine.
globostellata has been shown to produce a wide variety of isomalabaricanes, a type of triterpene molecules with notable cytotoxic activity towards certain cancer cell lines.
TRU-ADhanCe potency enhancing technology was designed to enhance the potency of existing therapies that work through Fc-directed or antibody-directed cellular cytotoxicity, or ADCC.