The most common Fc receptor on the surface of an NK cell is called CD16 or FcγRIII.
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To circumvent this problem, Greg Winter and his colleagues humanised Campath-1, by extracting the hypervariable loops that had specificity for CD52 and grafting them onto a human antibody framework.
Anti-glomerular basement membrane antibody (anti-GBM Ab) is an antibody which is found in Goodpasture's syndrome but not found in microscopic polyangiitis.
When Tse Wen Chang and Nancy T. Chang were setting up Tanox, Inc. in Houston, Texas in 1986, they purchased the rights on the antibody matrix patents from Centocor as part of the technology base to build their new startup.
Pioneering work by Noel Rose and Ernst Witebsky in New York, and Roitt and Doniach at University College London provided clear evidence that, at least in terms of antibody-producing B lymphocytes, diseases such as rheumatoid arthritis and thyrotoxicosis are associated with loss of immunological tolerance, which is the ability of an individual to ignore "self", while reacting to "non-self".
--> Adalimumab (which is a humanized recombinant antibody to TNF) showed effectiveness in patients with moderate-to-severe Crohn's disease, but less than that of infliximab.
Rodney Robert Porter, biochemist, won the 1972 Nobel Prize in Physiology or Medicine for discovering the structure of antibodies, Whitley Professor of Biochemistry from 1967-85 at the University of Oxford
The monkeys are used scientific research, including gene therapy, cancer, Parkinson's, Alzheimer's, stem cells and antibody-based treatments.
Cytokine release syndrome is a common immediate complication occurring with the use of anti-T cell antibody infusions such as ATG, OKT3 and TGN1412, but also with the CD-20 antibody rituximab.
Duligotumab (INN) is a human monoclonal antibody designed for the treatment of cancer.
The antibody Herceptin, which is used to treat breast cancers that overexpress the HER2/neu protein, has been tried with some success in a phase II trial in women with uterine papillary serous carcinomas that overexpress HER2/neu.
Because there is a great progress in development of antibodies, fluorochromes and multicolor digital flow cytometres, it became a question of how to interpret cytometric data and how to achieve comparable results between facilities.
Evolocumab is a fully human monoclonal antibody that inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9).
He has appeared in the films: "Non-Stop", The Corrections, The Bourne Legacy, The Bay, Black Dog/Red Dog, Deception, Able Danger, The House Is Burning (Cannes), Flannel Pajamas (Sundance), and Body/Antibody.
FITC (a fluorophore)-labeled anti-treponeme antibody and TRITC (another fluorophore)-labeled anti-human antibodies are added as secondary antibodies.
Futuximab (INN) is a chimeric monoclonal antibody designed for the treatment of cancer.
An international watershed in the publication and discussion of genetic evidence for ancient movements of people was that of Luigi Luca Cavalli-Sforza who used polymorphisms from proteins found within human blood (such as the ABO blood groups, Rhesus blood antigens, HLA loci, immunoglobulins, G-6-P-D isoenzymes, amongst others).
The Neonatal Fc receptor which in case of humans transfer the maternal antibody from mother through placenta to fetus, in this case is involved in transporting the IgG1 antibodies from mother animal's mammary gland into milk and then again from the ingested milk across the newborn intestine into the newborn animal's circulation.
Humanized antibody, a type of antibody modified to increase its similarity to human antibodies
Genetically-engineered intracellular antibody fragments called intrabodies have shown therapeutic results in fruit fly models, by inhibiting mHtt aggregation using an intrabody which binds to the end of mHtt within a cell.
Immunoglobulin D, an antibody protein involved in the maturation of B cells
Immunoglobulin heavy chain (IgH), the large polypeptide subunit of an antibody
Immunoglobulin kappa constant, also known as IGKC, is a human gene that encodes the constant domain of kappa-type light chains for antibodies.
IMAB362 is a monoclonal antibody against isoform 2 of Claudin-18.
Imgatuzumab (INN) is a humanized monoclonal antibody designed for the treatment of cancer.
IgG also plays an important role in antibody-dependent cell-mediated cytotoxicity (ADCC) and intracellular antibody-mediated proteolysis, in which it binds to TRIM21 (the receptor with greatest affinity to IgG in humans) in order to direct marked virions to the proteasome in the cytosol.
Antibody-drug conjugates, most, if not all, are immunotoxins but use whole antibodies and non-protein drugs
Diagnostic methods for the detection of the disease include: characteristic histological pancreatic lesion, PCR, indirect fluorescent antibody testing, ELISA, and virus culture.
Intracellular antibody-mediated degradation (IAMD) is a neutralization mechanism of intracellular antibody-mediated immunity whereby an effector protein, TRIM21, directs antibody bound virions to the proteasome where they are degraded.
Lampalizumab (INN) is a humanized monoclonal antibody designed for the treatment of geographic atrophy secondary to age-related macular degeneration.
Ligelizumab (INN) is a humanized monoclonal antibody that binds to IGHE.
Cetuximab, a monoclonal antibody against EGFR, has been used in compassionate use for treatment of Ménétrier's disease.
Orticumab (INN) is a human monoclonal antibody that is used as an anti-inflammatory agent and binds to oxLDL.
To establish that a disorder is an autoimmune disorder, Witebsky criteria requires that there be (1) a self-reactive antibody, (2) that a particular target for the antibody is identified (autoantigen) (3) that the disorder can be caused in animals and (4) that transferring antibodies from one animal to another triggers the disorder (passive transfer).
Perakizumab (INN) is a humanized monoclonal antibody designed for the treatment of arthritis.
The invention of antibody phage display by laboratories at the MRC Laboratory of Molecular Biology led by Greg Winter and John McCafferty, The Scripps Research Institute led by Richard Lerner and Carlos F. Barbas and the German Cancer Research Centre by Frank Breitling and Stefan Dübel revolutionised antibody drug discovery.
Quilizumab (INN) is a humanized monoclonal antibody designed for the treatment of asthma.
It is a monoclonal antibody that targets CD52, a protein that is expressed on the surface of mature lymphocytes.
Occurrence of the Sialyl Lewis A antigen, detected with the CA19-9 antibody, is highly correlated advanced epithelial cancers, such as stage III and stage IV colorectal cancers.
Simtuzumab (INN; formerly GS 6624) is a humanized monoclonal antibody designed for the treatment of fibrosis.
Single-domain antibody, an antibody fragment consisting of a single variable domain
Single-chain variable fragments lack the constant Fc region found in complete antibody molecules, and, thus, the common binding sites (e.g., Protein G) used to purify antibodies.
Supravital staining can be combined with cell surface antibody staining (immunofluorescence) for applications such as FACS analysis.
In 2012 Sutro formed a collaboration with Celgene worth over $500 million if all programs are successful to design and develop ADCs and bispecific antibodies for two undisclosed targets as well as manufacture a proprietary Celgene antibody using the company’s technology platform.
TRU-ADhanCe potency enhancing technology was designed to enhance the potency of existing therapies that work through Fc-directed or antibody-directed cellular cytotoxicity, or ADCC.
The antibody trastuzumab (Herceptin), which is used to treat breast cancers that overexpress the HER2/neu protein, has been tried with some success in a phase II trial in women with UPSCs that overexpress HER2/neu.
ELISA is a more modern variation of a protein assay that utilizes a specific antibody linked to an enzyme to detect the presence of an unknown amount of antigen (i.e. virus) in a sample.
xMAP (Multi-Analyte Profiling) technology is a multiplex assay format, patented by Luminex Corporation, using a panel of microspheres internally doped with two fluorescent dyes to produce up to 100 different bead identities that can be used in various applications - from HLA genotyping by oligonucleotide probe hybridization to serological profiling e.g. antibody diversity profiling, antibody identification or histocompatibility screen etc
Zatuximab (INN) is a chimeric monoclonal antibody designed for the treatment of cancer.