This blocks access to the cap by the decapping enzyme DCP2 and protects the message.
After being produced, the stability and distribution of the different transcripts is regulated (post-transcriptional regulation) by means of RNA binding protein (RBP) that control the various steps and rates of the transcripts: events such as alternative splicing, nuclear degradation (exosome), processing, nuclear export (three alternative pathways), sequestration in DCP2-bodies for storage or degradation, and ultimately translation.
DCP2 |
Charity evaluator GiveWell published a blog post in September 2011 cataloguing what they perceived to be errors in the cost-effectiveness estimates for deworming in the DCP2 report.