Twardzik grew up in Middletown, Pennsylvania, and played collegiately at Old Dominion University, where he was a two-time All American and led the Monarchs to the 1971 NCAA Division II title game.
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He drafted Bill Walton, Geoff Petrie, Larry Steele, Lloyd Neal, Lionel Hollins, Bobby Gross, Wally Walker and Johnny Davis, signed Dave Twardzik after the American Basketball Association folded, and selected Maurice Lucas in the ABA dispersal draft.