According to American Civil War-era dental handbooks from the mid-19th century, since the early 19th century metallic fillings had been used, made of lead, gold, tin, platinum, silver, aluminum, or amalgam.
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Bis-GMA based materials contain Bisphenol A, a known endocrine disrupter chemical, and may contribute to the development of breast cancer.
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In Europe, dental materials are classified as medical devices according to the Medical Devices Directive.
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