He performed, with the most modern techniques of the time, the first experimental analysis of the action of digitalis on warm-blooded animals and explained its effects, thereby increasing the drug's therapeutic use and value.
Digoxin (a mildly positive inotrope and negative chronotrope), once used as first-line therapy, is now reserved for control of ventricular rhythm in patients with atrial fibrillation; or where adequate control is not achieved with an ACEI, a beta blocker and a loop diuretic.
Digoxin |