Malesco is the most populous comune in Val Vigezzo and has a station on the Domodossola–Locarno railway which runs along the valley.
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He remained in Rome, attending theological lectures whilst residing at the Irish College in order to improve his English, and after his ordination to the priesthood, in 1830, proceeded to Domodossola to make his novitiate.
The construction of the new road over the Simplon Pass in 1801-05, the expansion of the old road between 1949–60 and the construction of a national highway starting in 1960, have allowed increasing traffic through Brig. In 1890-1905 stagecoaches transported 152,816 persons to Domodossola over the pass.
The train station in the municipality on the Locarno-Domodossola line was built in 1923.
Between 1889-93, the main road was built, followed in 1923 by a station on the Locarno-Domodossola railway line.
For nearly two decades (1666–1684), he worked in the sacri monti of Orta San Giulio, Varallo Sesia, Varese, and Domodossola.
Its strategic location accommodates Swiss rail passengers, and Domodossola railway station acts as an international stopping-point between Milan and Brig (a Swiss city of German language) through the Simplon Pass (Italian: Sempione).
He also contributed to the Certosa di Pavia and sent many sculptures for the Sacri Monti of Piedmont and Lombardy, including to Monte Calvario; to the 9th, 10th, and 15th chapels of the Sacri Monti of Domodossola; to the 13th and 19th chapels of the Sacri Monti of Orta; and the statues of SS Domenico and Francisco in the high altar (1660–1662) for the Sacri Monti of Varese .
Intragna has good railway connection with Locarno, Switzerland and Domodossola, Italy, as well as bus connections that lead to various hiking routes.
After a course of 13 km, which takes it through the commune of Masera and entails a descent of about 2000 m, it joins the Toce near Domodossola.
the construction of a narrow gauge railway Locarno - Domodossola.
Besieging Domodossola and marauding the valleys, the Swiss were decisively defeated by the Ducal Milanese at the Battle of Crevola in April 1487.
Vincenzo de Vit (b. Mestrina, near Padua, 10 July 1810; d. Domodossola, 17 August 1892) was an Italian Latin scholar and historian of Ancient Rome.