A first setback came with the Battle of Arbedo in 1422, where the Swiss were defeated by the Duchy of Milan, and in a treaty of 1426, the border of the duchy was moved back to the Gotthard Pass.
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Besieging Domodossola and marauding the valleys, the Swiss were decisively defeated by the Ducal Milanese at the Battle of Crevola in April 1487.
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