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The line is also used by rail passengers changing at Dublin Connolly onto the DART to Dún Laoghaire for the Stena Line ferry to Holyhead, or travelling to Dublin Port for the Irish Ferries to Holyhead, and then by train along the North Wales Coast Line to London Euston and other destinations in England and Wales.
Isle of Inishmore began her career on Irish Ferries' Dublin-Holyhead route as the flagship of the company's fleet, replacing the 1995 built Isle of Innisfree.