Commercial activities in the province are centered on the provincial capital of Borongan City while tourism activities are centered in Guiuan town where Calicoan Island and the historical Homonhon Island are located.
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Mid-Sea Express plies Cebu-Guiuan route to serve tourists going to Calicoan Island.
It is the location of Battery Hartshorne, named on November 18, 1902 in honor of Captain Benjamin M. Hartshorne, Jr., 7th U. S. Infantry, who was killed January 2, 1902, in action with insurgents near Lanang, Samar, Philippine Islands during the Philippine–American War.
By 24 January 1945, four fighter squadrons from MAG-14 were operating from Guiuan in the northern Philippines province of Eastern Samar.
Several hours later, the eye of the cyclone made its first landfall in the Philippines at Guiuan, Eastern Samar, without any change in intensity; if verified, this would make Haiyan the strongest tropical cyclone to make a landfall on record, surpassing the old record of 305 km/h (190 mph) set by Atlantic Hurricane Camille in 1969.
On January 11, 1945, the squadron, along with other from MAG-14, landed on the island of Guinan in the Philippines.
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