These included the Bessbrook and Newry Tramway, the Snaefell Mountain Railway the Blackpool and Fleetwood tramways and the City and South London Railway.
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His elder brothers included the noted physicist and engineer John Hopkinson, and Sir Alfred Hopkinson, vice-chancellor of the University of Manchester, and amongst his nephews were engineer and scientist Bertram Hopkinson, and Austin Hopkinson, MP.
On 15 January 1922 Edward Hopkinson, Member of Parliament for Manchester Clayton, died and Flanagan was adopted as Coalition Unionist candidate for the resulting by-election.
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