Princess Elisabeth Therese was born at the Château de Lunéville and was the ninth of eleven children of Leopold Joseph of Lorraine and his wife Élisabeth Charlotte d'Orléans.
His paternal family, the Guise's were a cadet branch of the House of Lorraine, the sovereign Dukes of Lorraine; as such Louis could count the future Francis I, Holy Roman Emperor and a Queen of Sardinia as cousins.
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