He was an avid reader and book collector and, eventually, attracted the interest of New York publishing magnate, William Jovanovich.
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He made his debut with the Philadelphia Orchestra with Eugene Ormandy, playing a concerto by Chopin, and the New York Philharmonic conducted by Artur Rodziński playing Brahms' Piano Concerto No. 2 in the same week in 1943.
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As late as 2001, he made the world premiere recording of Paul Paray's Fantaisie for Piano and Orchestra, with the Budapest Symphony Orchestra under Jean-Bernard Pommier.
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His earliest public performances began at age six with his mother, and at 12 he entered the Curtis Institute, having had earlier advice from Alexander Siloti and his daughter Kyriena.
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In 1980, Istomin was hired by Harcourt Brace Jovanovich Publishers to advise the company in the publication of facsimile editions of original editions by Joseph Conrad and Thomas Hardy, among others.
Eugene O'Neill | Eugene, Oregon | Eugène Delacroix | Eugene Onegin | Eugène Ionesco | Eugene | Eugene Onegin (opera) | Eugene McCarthy | Pope Eugene IV | Eugène Ysaÿe | Eugene Wigner | Eugene Field | Eugene Aynsley Goossens | Gene Eugene | Harold Eugene Edgerton | Eugene Levy | Eugène de Beauharnais | W. Eugene Smith | Pope Eugene III | Eugene Ormandy | Eugene Jolas | Eugene Fama | Eugene Cernan | Eugène Atget | David Eugene Edwards | H. Eugene Stanley | Eugene V. Debs | Eugene Nickerson | Eugene Chadbourne | Eugene Braunwald |