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The inclusion or skipping of the exon depends on two antagonistic proteins, TIA-1 and polypyrimidine tract-binding protein (PTB).
Eteplirsen is a Morpholino antisense oligomer which triggers excision of exon 51 during pre-mRNA splicing of the dystrophin RNA transcript.
The technique has largely been supplanted by the approach of sequencing cDNA generated from mRNA and then using bioinformatics tools such as NCBI's BLAST server to determine the source of the sequence, thereby identifying the appropriate exon-intron splice sites.
Disruption of an exon splicing ehancer in exon 3 of MLH1 gene is the cause of HNPCC (hereditary non polyposis colorectal cancer) in a Quebec family.
The port security provisions were one of 20 bills introduced to Congress in the wake of the Dubai Ports World controversy that aimed to block Dubai Ports World acquiring P&O Ports, and more generally to stop key US ports falling into the hands of foreign owners by changing the Exon-Florio Amendment.