Since mRNA is the starting material, the amount of sequence representation for a given gene will be based on the expression level (how many mRNA molecules it produces).
It is an Hfq-dependent RNA which downregulates AfaD-VIII invasin translation by binding to and initiating cleavage of its mRNA.
Antizyme RNA frameshifting stimulation element is a structural element which is found in antizyme mRNA and is known to promote frameshifting.
Benoit Coulombe is a Canadian scientist whose research focuses on the mechanisms by which regulated protein–protein, protein–DNA and protein–RNA interactions control the activity of RNA polymerase II, the molecular machine that synthesizes all messenger RNA (mRNA) and some small-nuclear RNA (snRNA) in eukaryotes.
C14orf102 interacts with RNPS1, a gene encoding a protein that is known to be directly involved in nuclear export and surveillance of mRNA.
Treatment with melatonin in old mice with age related liver inflammation decreased the mRNA expression of TNF-α, IL-1β, HO (HO-1 and HO-2), iNOS, CCL2, NF-κB1, NF-κB2 and NKAP in old male mice.
For example, it was shown that β-actin zipcode binding protein 1 (ZBP1) - dependent dendritic mRNA transport contributes to proper dendritic branching.
Northern blot analysis several days after CREB overexpression showed a marked increase in dynorphin mRNA in the nucleus accumbens.
EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.
Eteplirsen is a Morpholino antisense oligomer which triggers excision of exon 51 during pre-mRNA splicing of the dystrophin RNA transcript.
It is transcribed by RNA polymerase II to give an mRNA that codes for two proteins: ORF1 and ORF2, which are necessary for transposition.
The technique has largely been supplanted by the approach of sequencing cDNA generated from mRNA and then using bioinformatics tools such as NCBI's BLAST server to determine the source of the sequence, thereby identifying the appropriate exon-intron splice sites.
The enzymes for capping can only bind to RNA polymerase II ensuring specificity to only these transcripts, which are almost entirely mRNA.
The insulin-like growth factor II (IGF-II) internal ribosome entry site IRES is found in the 5' UTR of IGF-II leader 2 mRNA.
The defective gene associated with LCCS1 is mRNA export mediator GLE1 at chromosome 9q34.
The biosynthesis is (e.g. T4) regulated in three phases of mRNA production followed by a phase of protein production.
Upon export from the nucleus the mRNA associates with ZBP1 and the 40S subunit.
Western blot analysis shows that homozygous cycle0 mutants have very little PER and TIM protein as well as low per and tim mRNA levels.
Makeyev et al. showed that miR-124 directly targets PTBP1 (PTB/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells.
miR-134 is a brain-specific microRNA; in rats it is localised specifically in hippocampal neurons and may indirectly regulate synaptic development through antisense pairing with LIMK1 mRNA.
IFRD1 is a positive cofactor of MyoD, as it cooperates with MyoD at inducing the transcriptional activity of MEF2C (by displacing HDAC4 from MEF2C); moreover IFRD1 also represses the transcriptional activity of NF-κB, which is known to inhibit MyoD mRNA accumulation.
Polypyrimidine tract-binding protein is an RNA-binding protein, also known as PTB or hnRNP I. PTB functions mainly as a splicing regulator, although it is also involved in alternative 3' end processing, mRNA stability and RNA localization.
It is believed that these RNAs, guided by a protein, Hfq, can mediate the destabilisation of the quorum-sensing master regulators LuxR/HapR/VanT mRNAs.
Negative-sense viral RNA is complementary to mRNA and thus must be converted to positive-sense RNA by an RNA polymerase before translation.
This sequence is recognised by a cytosolic protein, SRP (Signal Recognition Particle), which stops the translation and aids in the transport of the mRNA-ribosome complex to an SRP receptor found in the membrane of the endoplasmic reticulum.
The hairpin loop forms in an mRNA strand during transcription and causes the RNA polymerase to become dissociated from the DNA template strand.
General transcription factors These transcription factors position RNA polymerase at the start of a protein-coding sequence and then release the polymerase to transcribe the mRNA.
Tryptophan, an essential amino acid in the human diet (mRNA genetic code)
Untranslated region, one of the two sections on each side of a coding sequence on a strand of mRNA
They starts by shutting off host cell transcription by inhibiting mRNA nuclear export through direct interaction with the host RAE1-NUP98 complex.
This region has been shown to mediate internal ribosome entry in cells derived from brain, heart, and skeletal muscle; tissues known to express mRNA species.
EPRS is a component of the interferon-gamma-activated inhibitor of translation (GAIT) complex, which interacts with stem-loop elements (GAIT elements) in mRNAs encoding proinflammatory proteins, for example, vascular endothelial growth factor-A (VEGFA).