Fibroblast growth factor, a family of growth factors involved in angiogenesis, wound healing, and embryonic development
FGF |
Secreated anosmin-1 enhances FGF activity by promoting FGF8-FGFR1 complex formation, whereas inhibits both BMP5 and WNT3A activities.
Activation of FGF by two ligands that function together, FGF4 and FGF8 (17) in Xenopus and FGF8 and FGF24 in zebrafish (18), is necessary for mesoderm formation.
Many signaling pathways contribute to this reorganization, including BMP, FGF, nodal, and Wnt.
Osteocyte specific proteins such as sclerostin have been shown to function in mineral metabolism, as well as other molecules such as PHEX, DMP-1, MEPE, and FGF-23, which are highly expressed by osteocytes and regulate phosphate and biomineralization.
Pdx1+ pancreatic progenitor cells also co-express Hlxb9, Hnf6, Ptf1a and Nkx6-1, and these progenitor cells form the initial pancreatic buds, which further proliferate and branch in response to FGF-10 signaling.