After the defeat of the French in the Battle of Fornovo (6 June 1495) and the restoration of the Aragonese in Naples the same month, Virginio was arrested and imprisoned by Ferdinand II of Naples, the new Neapolitan king, with the consent of the Pope.
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Charles VIII expelled Alfonso II of Naples from Naples in 1495, but was soon forced to withdraw due to the support of Ferdinand II of Aragon for his cousin, Alfonso II's son Ferrantino.