Perini was born in Rome, where she studied at the Accademia Nazionale di Santa Cecilia before making her professional opera début at La Scala in 1908 as Anacoana in Franchetti's Cristoforo Colombo.
Afdera Franchetti was the daughter of Baron Raimondo Franchetti, a famous explorer who traveled extensively in Ethiopia and chartered hitherto unexplored territories (Dancalia) during the 1920s.
During his 45 years in the United States, Franchetti received composition honors and awards from the Guggenheim Foundation, the National Endowment for the Arts, National Institute of Arts and Letters, and many other prestigious organizations.
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Urban legend has it that Luigi Illica's libretto of Tosca was first offered to Franchetti who, too busy at the time with other projects, passed it on to his friend Puccini.
Asrael is an opera by Alberto Franchetti that premiered in 1888
The two remained together for just over a year, until Franchetti left Capri and linked with the prominent American artist Romaine Brooks.
Leopoldo Franchetti's half of the report, Political and Administrative Conditions in Sicily, was an analysis of the Mafia in the nineteenth century that is still considered authoritative today.