Following work on a number of apartment buildings and private residences, Gianotti was commissioned to design the La Inmobiliaria Building (on Avenida de Mayo) in 1910, and Galería Güemes in Florida Street, possibly one of his best works, in 1913; with 14 floors, and a height of 80 m, it was considered to be the first skyscraper in Buenos Aires.
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During the early part of the 20th century there were many immigrant Italian architects working in Buenos Aires including Francesco Tamburini, who designed the Teatro Colón, Vittorio Meano, who designed the Argentine National Congress, Mario Palanti, who designed the Palacio Barolo, Francisco Gianotti who designed the Confitería El Molino, and Juan Antonio Buschiazzo who made alterations to the Centro Cultural Recoleta and designed the Italian Hospital.