Weedon was the son of Sarah Sands and William Weedon who served as a colonel during the American Revolutionary War.
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He served in the Fourth Florida Infantry of the Confederate States Army and was later in charge of the Confederate hospital in Eufaula, Alabama during the American Civil War.
After his death his skull was defleshed by the attending physician Frederick Weedon from St. Augustine who kept it as a macabre curio.
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