Glutamate cysteine ligase modifier subunit (GCLM, ~31 kDa) increases the catalytic efficiency of GCLC.
Glutamate-cysteine ligase, catalytic (Gclc) and glutamate-cysteine ligase, modifier (GCLM) subunits form a heterodimer, which is the rate-limiting step in the synthesis of glutathione (GSH), a very powerful endogenous antioxidant.
GCLM |