The reduction of dehydroascorbate may be non-enzymatic or catalysed by proteins with dehydroascorbate reductase (DHAR) activity, such as glutathione S-transferase omega 1 or glutaredoxins.
The MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation.
Glutamate-cysteine ligase, catalytic (Gclc) and glutamate-cysteine ligase, modifier (GCLM) subunits form a heterodimer, which is the rate-limiting step in the synthesis of glutathione (GSH), a very powerful endogenous antioxidant.