Seeking help abroad, O'Keefe consulted with German winemaker Karl Werner, who put him in touch with Helmut Becker, chief viticulturist of the Geisenheim Grape Breeding Institute in Germany.
In 1876 professor Hermann Müller from Switzerland joined the institution, where he developed his namesake variety Müller-Thurgau (with Thurgau being his home canton), which became the most planted grape variety in Germany in the 1970s.
He died in Geisenheim, which is still famous for its wine and the Geisenheim Grape Breeding Institute.
In the semester 2008/2009 he took lessons at the University of Applied Sciences in Geisenheim comprising the Geisenheim Grape Breeding Institute.
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