At least 150,000 babies were born at the hospital and it is said that Florence Nightingale took a personal interest in the associated midwifery training school.
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Since March 2013 the building comprises part of the Premier Inn Hotel Waterloo.
It became a maternity hospital and a facility for training pupil midwives by the General Lying-In Hospital which had been evacuated from York Road, Lambeth, (Waterloo), in central London.
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The hospital, originally known as "The Dublin Lying-In Hospital", was founded in 1745 by Bartholomew Mosse (1712-1759), a surgeon and man-midwife who was appalled at the conditions that pregnant mothers had to endure at the time.