He was married to Ramona Pelayo-Ejercito of Ibajay, Aklan, with whom he had four children: actor Emilio Ramon Ejercito ("George Estregan, Jr."), Maria Georgina Ejercito, Kurt Joseph Ejercito, and George Gerald Ejercito.
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Estregan was the son of Emilio Ejercito, Sr. (1898–1977) and Mary Ejercito, as well as the younger brother of former Philippine President Jose "Joseph" Ejercito (Joseph Estrada).
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Born Emilio Ramon Pelayo Ejército on October 5, 1963 in Pagsanjan, Laguna to action star Jorge Marcelo Ejercito, who went by the screen name George Estregan, of Pagsanjan, Laguna and Ramona Pelayo Ejercito in Ibajay, Aklan.