He was associated with the Dutch literary group known as the Tachtigers (English translation: "Eighty-ers").
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Witsen wrote under a pseudonym in the literary magazine De Nieuwe Gids, which he also supported financially.His circle of friends included the painters George Hendrik Breitner, Isaac Israëls, and Jan Veth and the writers Lodewijk van Deyssel, Albert Verwey, Willem Kloos, and Herman Gorter.