Girolamo had six sons, Ottaviano, who officially inherited the lordship of Imola, Cesare, Giovanni Livio, Galeazzo, Francesco, and a daughter, Bianca by his wife, Caterina, and lastly an illegitimate son by another woman, named Scipio.
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In 1488 he was the last of the main Pazzi conspirators left alive, and was himself assassinated in a conspiracy led by two members of the Orsi family from Forlì, supposedly over a financial dispute.
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Having taken part in the 1478 Pazzi Conspiracy against the Medici, 10 years later he was assassinated by members of the Forlesian Orsi family.
Girolamo Savonarola | Girolamo Frescobaldi | Girolamo Tiraboschi | Girolamo "Jimmy" Palermo | Girolamo Rusticucci | Girolamo Riario | Girolamo Porro, ''Antique map of Iceland'', from the National and University Library of Iceland | Girolamo Muziano | Girolamo Maggi | Girolamo Li Causi | Girolamo Fracastoro | Girolamo Benivieni | ''Saint Mary Magdalene approaching the Sepulchre'' by Girolamo Savoldo | Ottaviano Riario | Girolamo Zoppio | Girolamo Sernigi | Girolamo Segato | Girolamo Savoldo | Girolamo Sartorio | Girolamo Santacroce | Girolamo Piromalli | Girolamo Montesardo | Girolamo Mercuriale | Girolamo Maiorica | Girolamo Di Fazio | Girolamo da Carpi | Girolamo Cavazzoni | Girolamo Caraffa | Girolamo Benzoni |
Sixtus IV appointed his nephew, Girolamo Riario, as the new governor of Imola, and Francesco Salviati as archbishop of Pisa, a city that was a former commercial rival but now subject to Florence.
In 1488, Pope Innocent VIII sent Cardinal Riario as a legate to his maternal uncle Girolamo Riario, at the time governor of Forlì and Imola, who was revolting against the Holy See.