Sixtus IV appointed his nephew, Girolamo Riario, as the new governor of Imola, and Francesco Salviati as archbishop of Pisa, a city that was a former commercial rival but now subject to Florence.
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On Sunday, 26 April 1478, during High Mass at the Duomo before a crowd of 10,000, the Medici brothers were assaulted.
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Having taken part in the 1478 Pazzi Conspiracy against the Medici, 10 years later he was assassinated by members of the Forlesian Orsi family.
A Tabernacle for the Sun (2005), the first volume of Linda Proud's Botticelli Trilogy, tells the story of the Pazzi Conspiracy from the point of view of Tommaso de' Maffei, half-brother of one of the conspirators.