In the theory of grand unification of particle physics, and, in particular, in theories of neutrino masses and neutrino oscillation, the seesaw mechanism is a generic model used to understand the relative sizes of observed neutrino masses, of the order of eV, compared to those of quarks and charged leptons, which are millions of times heavier.
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Specific Grand unified theories (GUTs) can predict the grand unification energy but, usually, with large uncertainties due to model dependent details such as the choice of the gauge group, the Higgs sector, the matter content or further free parameters.
At the same time, most of the modern Grand unification theories such as M-theory predict no magnetic monopoles, which casts doubt on this attractive idea.