Great Wagon Road, a historic road from Pennsylvania south into North Carolina
The English, Anglo-Scottish, and Scots-Irish from the Anglo-Scottish border area were the largest group of settlers from the British Isles before the American Revolution.
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Conococheague Creek continues south into Maryland and enters the Potomac near Williamsport, where the Great Philadelphia Wagon Road crossed the river at William's Ferry, continuing on to Winchester, Virginia.
This portion of the road was also part of Daniel Boone's Wilderness Road which allowed those following the Great Wagon Road to continue past present-day Bristol, through the Reedy Creek Settlement, through Moccasin Gap, and over to Cumberland Gap to settle in Kentucky.