Nicolò Guarco (Parodi, c.1325-Lerici, c.1385) was a Genoese politician and statesman who became the 7th doge of the Republic of Genoa and led the Republic through the War of Chioggia against Venice.
With the old patriciate excluded from power, a new class of mercantile houses arose: Adorno, Guarco, Fregoso, and Montaldo.