Drugs, such as the statins, stop the production of mevalonate by inhibiting HMG-CoA reductase.
Patients have markedly reduced whole-body cholesterol biosynthesis associated with suppressed hepatic, ileal, and mononuclear leukocyte hydroxymethylglutaryl-coenzyme A reductase (HMG-CoA reductase), the rate-controlling enzyme in the cholesterol biosynthetic pathway.
5-alpha reductase | HMG-CoA reductase | Rubredoxin—NAD(P)+ reductase | Ribonucleoside-triphosphate reductase | GMP reductase | Flavanone 4-reductase | D-xylose reductase | Acetyl-CoA C-acyltransferase |
Statins are another class of drugs that inhibit the HMG-CoA reductase pathway.
MG-42\59) MMG for the SK-105A-1 Kurassier LT, the US 7.62mm M1919A4 MMG, and the .50BMG M2 Browning HMG.
If hypercholesterolemia is not controlled with CDCA, an HMG-CoA reductase inhibitor ("statins" such as simvastatin) can also be used.
In 2002, Federico Mayor Zaragoza co-founded with Boutros Boutros Ghali, John Brademas, Edward J. Nell, Karim Errouaki and Alain Chanlat the Centre Humanism, Management & Globalization (HMG) at HEC-Montreal.
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The Center HMG was launched during an International colloquium organized by Edward J. Nell and Karim Errouaki (who was then the first Director of the Center HMG (2002–2004)) and Alain Chanlat (then Director of CETAI HEC-Montreal), and was held at HEC-Montreal in March 2003.The event was sponsored by HEC-Montreal, the Foundation for a Culture of Peace, and the Gorbachev Foundation of North America.
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HEC-Montreal was the HMG headquarters and the New School (NY) was the main research unit under the co-directorship of Edward J. Nell and Karim Errouaki.